Gene Knockout Identification Using an Extension of Bees Hill Flux Balance Analysis
نویسندگان
چکیده
منابع مشابه
Gene Knockout Identification Using an Extension of Bees Hill Flux Balance Analysis
Microbial strain optimisation for the overproduction of a desired phenotype has been a popular topic in recent years. Gene knockout is a genetic engineering technique that can modify the metabolism of microbial cells to obtain desirable phenotypes. Optimisation algorithms have been developed to identify the effects of gene knockout. However, the complexities of metabolic networks have made the ...
متن کاملUsing Bees Hill Flux Balance Analysis (BHFBA) for in silico Microbial Strain Optimization
Microbial strains can be manipulated to improve product yield and improve growth characteristics. Optimization algorithms are developed to identify the effects of gene knockout on the results. However, this process is often faced the problem of being trapped in local minima and slow convergence due to repetitive iterations of algorithm. In this paper, we proposed Bees Hill Flux Balance Analysis...
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The increasing demand of biochemical supply for various industries has spurred the development of metabolic engineering to find the optimal design of the microbial cell factories. Traditional method of chemical synthesis using the natural producer leads to the production far below their theoretical maximums. Gene knockout strategy is then introduced to improve the metabolite production. To aid ...
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Reconstructions of genome-scale metabolic networks from different organisms have become popular in recent years. Metabolic engineering can simulate the reconstruction process to obtain desirable phenotypes. In previous studies, optimization algorithms have been implemented to identify the near-optimal sets of knockout genes for improving metabolite production. However, previous works contained ...
متن کاملDifferential Bees Flux Balance Analysis with OptKnock for In Silico Microbial Strains Optimization
Microbial strains optimization for the overproduction of desired phenotype has been a popular topic in recent years. The strains can be optimized through several techniques in the field of genetic engineering. Gene knockout is a genetic engineering technique that can engineer the metabolism of microbial cells with the objective to obtain desirable phenotypes. However, the complexities of the me...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2015
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2015/124537